Codexis, Inc.

Biotechnology • Healthcare • Redwood City, CA, United States • CDXS (NMS) • Website

Codexis, Inc. provides enzymatic solutions for therapeutics manufacturing, leveraging its proprietary CodeEvolver technology platform to discover, develop, and enhance novel enzymes in the United States, Canada, Latin America, Europe, the Middle East, Africa, Australia, New Zealand, Southeast Asia, and China. The company develops its proprietary ECO Synthesis manufacturing platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. It has a license agreement with Aldevron LLC and Pfizer Inc. The company was incorporated in 2002 and is headquartered in Redwood City, California.

Stock Performance (90 Days)

Data through Nov 14, 2025

Layoff Events

Earnings Calls

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Layoff History

46 (5 sources) employees (24.0%)

Nov 11, 2025

5 sources

Reason

Codexis, Inc. implemented a workforce reduction of approximately 24% (46 positions) coinciding with a change in company leadership, with Dr. Alison Moore succeeding Dr. Stephen Dilly as CEO, effective November 7, 2025. This strategic overhaul, announced on November 6, 2025, aims to streamline operations, reduce operational expenses by recognizing an approximate $3.5 million expense in the fourth quarter of 2025, and extend the company's cash runway through 2027. The company is pivoting its strategic focus away from small molecule biocatalysis due to pricing pressures and towards innovative manufacturing solutions in its ECO Synthesis platform for oligonucleotide production. This includes reducing sales and marketing efforts in the small molecule biocatalysis segment. The workforce reduction is expected to be substantially completed by January 2026.

Affected Departments

Small Molecule Biocatalysis (especially sales and marketing)Other departments not aligned with ECO Synthesis platform

Affected Locations

Redwood CityCA

Source: Companies that announced Major Layoffs and Hiring Freezes | Intellizence View Source →

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